I. Demirhan*

Vocational School of Health Services, Harran University, Sanl?urfa 63300, Turkey

*Corresponding Author:
I. Demirhan
Vocational School of Health Services, Harran University, Sanl?urfa 63300, Turkey
E-mail: ilterdemirhan@gmail.com
Date of Received 09 February 2022
Date of Revision 18 April 2023
Date of Acceptance 06 February 2024
Indian J Pharm Sci 2024;86(1):54-63  

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms

DOI: 10.36468/pharmaceutical-sciences.1251

Abstract

This study was aimed to investigate the performance of the extracted Hypericum Perforatum wound dressings produced by three different fabrication techniques. The effect of electrospinning, three dimensional printing, hydrogel casting techniques on the properties of the wound dressings were exhibited. Morphological, physical and chemical properties and differences of the resulting samples were established using Fourier transform infrared spectroscopy, scanning electron microscopy, mechanical and differential scanning calorimetry tests. Antimicrobial analysis of the patches was evaluated against Escherichia coli and Staphylococcus aureus strains. The results indicate that fabrication techniques affect the dressing patches utilizing surface chemical compositions and mechanical performances. Patches were highly effective against bacterial infections for both gram-negative and gram-positive. The highest area of the antibacterial effect belongs to the electro spinning case, which has 12 mm diameter on gram-positive bacteria thanks to the potassium rich surface chemistry of the fibers. In summary, these fascinating findings will lead to patches that can prevent over usage of antibiotics and the formation of new antibiotic resistivity. The plant Hypericum perforatum has the potential antibacterial effect for the Escherichia coli and Staphylococcus aureus strains. However, it was carried out for the first time that it could be used as a wound dressing.

ARTICLE WAS RETRACTED