Abstract

Panchagavya is a term used in Ayurveda to describe the five important bovine products, milk, curd, ghee, urine and dung. Several formulations based on panchagavya are reported in Ayurvedic texts. One such formulation, Chandanadi Yamak was tested in the present study for its topical wound healing activity. Studies were conducted in male Wistar rats. Two wound models, incision wounds for tensile strength and excision wounds for wound contraction were employed along with histopathological evaluation. The application of the test formulation alone promoted wound contraction and reduced the time for wound closure showing healing potential comparable to marketed framycetin sulphate cream (1% w/w).The histological studies reveal complete healing with the test formulation showing good keratinization, epithelialization, fibrosis and angiogenesis. The present study demonstrates the wound healing potential of the test formulation.