Abstract

Two visible spectrophotometric and one HPLC method have been developed for estimation of rimapril from its capsule formulation. The developed visible spectrophotometric methods were based on formation of chloroform extractable coloured complexes of drug with nitrosonaphthol and with bromophenol blue. The formed coloured complex with nitrosonaphthol showed absorbance maximum at 445.5nm and Beer's law was obeyed in the concentration range of 50-300mug/ml of drug while the formed coloured complex with bromophenol blue showed absorbance maximum at 414nm and Beer's law was obeyed in the concentration range of 20-100mug/ml of rimapril. Developed HPLC method was a reverse phase chromatographic method using Inertsil C(18) column and methanol:acetate buffer::80:20 as mobile phase with detection at 230nm. Loratidine was used as internal standard for the HPLC method. Linearity was observed in concentration range of 10-300mug/ml of rimapril. Results of analysis for all the methods were validated statistically and by recovery studies.