Validated TLC densitometric method for the quantification of paroxetine hydrochloride in solid dosage form

RN Sharma1; MS Bagul2; SC Chaturvedi1; KK Vasu2; M Rajani2

doi:10.4103/0250-474X.34557

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Abstract

Validated TLC densitometric method for the quantification of paroxetine hydrochloride in solid dosage form

Author(s): RN Sharma¹, MS Bagul², SC Chaturvedi¹, KK Vasu², M Rajani²
¹ School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore - 452 017, India ² B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Thaltej-Gandhinagar Highway, Thaltej, Ahmedabad - 380 054, India

Correspondence Address:
M Rajani B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Thaltej-Gandhinagar Highway, Thaltej, Ahmedabad - 380 054 India E-mail: perd@perdcentre.com

DOI: 10.4103/0250-474X.34557

A simple, specific, accurate and precise high performance thin layer chromatography method has been developed for the estimation of paroxetine hydrochloride in tablet dosage forms. The quantification was carried out at 296 nm. Developed method was validated in terms of linearity, accuracy, precision, repeatability and specificity. Limit of detection and limit of quantification of paroxetine hydrochloride were found to be 60 ng/spot and 160 ng/spot, respectively. The linearity range for paroxetine hydrochloride was found to be 160-960 ng/spot with correlation coefficient of 0.995. Content of paroxetine hydrochloride in two tablet dosage forms was found to be 100.10 and 100.20%, respectively.

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