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Abstract
Validated analytical methods of repaglinide in bulk and tablet formulations
Author(s): SJ Rajput, BG Chaudhary
Four validated spectrophotometric methods for the estimation of repaglinide in bulk drug and its tablet formulations have been developed. Method I is extractive spectrophotometric method based on the formation of a yellow coloured ion-pair of repaglinide with bromothymol blue. Method II is a simple UV spectrophotometric method, and methods III and IV are based on derivative and difference spectroscopy respectively. Quantitative recoveries were obtained from bulk and from marketed tablet formulations. Various validation parameters were also studied.
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