Abstract

To investigate the therapeutic value of Mahuang Fuzi Xixindecoction in Chinese medicine and its effect on the improvement of serum interleukin-10, interferon‐gamma and nuclear factor kappa B levels for allergic rhinitis. 110 individuals with allergic rhinitis admitted to our hospital from December 2021 to December 2022 were selected and were divided into 2 groups, control and observation group. Control group were given loratadine tablets (Western drug treatment) orally once a day for 1 mo while the observation group was given Mahuang Fuzi Xixin decoction. All the individuals were observed for the presence of primary and secondary traditional Chinese medicine symptoms such as nasal congestion, nasal itching, fear of wind and cold after treatment, cough, thin sputum or pallor, respectively. According to the traditional Chinese medicine symptom score scale, tumor necrosis factor-alpha, interleukin-6 and immunoglobulins, etc., and the adverse reactions were investigated. Treatment with Mahuang Fuzi Xixindecoction had a significant improvement in the improvement of symptoms in the subjects compared to the statistics of the control group (p<0.01). Further, efficacy evaluation showed that the overall effective rate of 90.91 % in the individuals with allergic rhinitis which was significantly higher than that of the control group. At the completion of the treatment, we noticed a significant improvement in observation group by evaluating sneezing and nasal congestion. Laboratory tests suggested that the serum inflammatory factors such as interferon‐gamma, tumor necrosis factor-alpha, C-reactive protein and laboratory-measured immunoglobin E levels reduced in the observation group after treatment of Ephedra sinensis, which assisted in alleviating the immune imbalance in individuals. Compared to the control group, the incidence of adverse reactions was significantly lower in the observation group than in the control group. It is suggested that a relatively good safety profile exists for Ephedra dosing regimen. It has certain affirmative efficacy and satisfactory safety record in the treatment of allergic rhinitis compared with Western drug regimens, which can not only help patients to regulate their own immune imbalance but also help them to reduce their symptoms. It has favorable advantages and is worth of clinical promotion in the diagnosis and treatment of allergic diseases.