Abstract

In order to explore the prevalence of thalassemia among the Yao population in Guangdong Province, China, the situation of β and α thalassemia patients in the district is analyzed by Hb hemoglobin electrophoresis and gene detection. The results have shown that the proportions of CD17 and βE to the positive β-thalassemia patients are the highest, which are the most common types of the β-thalassemia gene mutations; the β-thalassemia gene double heterozygous mutation is the least; in addition, the α-thalassemia gene detection has shown that among the positive mutation types, the αα/αα has accounted for the largest proportion, and the αα3.7/αα mutation case is the least. In summary, due to the high coincidence of β-thalassemia positive rates degree between the hemoglobin electrophoresis detection and the gene diagnosis, the higher positive rate of hemoglobin electrophoresis would indicate the higher β-thalassemia gene carrying rate and incidence rate to some extent. Therefore, to a certain extent, it can be considered that the incidence of α-thalassemia is less different among different ethnic groups and regions in Guangdong Province; however, there is a significant difference between β-thalassemia among the Yao nationality and other ethnic groups in Guangdong Province.