Abstract
TGF-β/FAK/AKT Signal Pathway Blocked by Astragaloside, Hinders the Invasion and Metastasis of Non-Small Cell Lung Cancer
Department of Integrated Traditional Chinese and Western Medicine Pulmonary Disease, Zigong First People's Hospital, Zigong 643000, 1Department of Oncology and Hematology, Sichuan Science City Hospital, Mianyang, Sichuan Province 621000, China
Correspondence Address:
Xin Chen, Department of Integrated Traditional Chinese and Western Medicine Pulmonary Disease, Zigong First People's Hospital, Zigong 643000, China, E-mail: tuchengzhanfan0540@163.com
The aim of this study is to examine the suppressive impact of astragaloside on the invasion and spread of non-small cell lung cancer by obstructing the transforming growth factor-beta/focal adhesion kinase/protein kinase B signaling pathway. Sixty mice were categorized into three groups; the normal control group (n=20) (group A), the model control group (n=20) (group B), and the astragaloside IV intervention group (n=20) (group C). To establish the non-small cell lung cancer mouse model for group B and group C, the modulated PC9/ER cell suspension was injected into the left axilla of nude mice, whereas group A received an equivalent amount of normal saline instead. After successful modeling, mice in group C were given astragaloside 30 mg/kg by intragastric administration. The expression levels of transforming growth factor-beta, focal adhesion kinase, and protein kinase B messenger ribonucleic acid were higher in group B compared to group A, whereas the expression levels of transforming growth factor-beta, focal adhesion kinase, and protein kinase B messenger ribonucleic acid were lower in group C compared to group B. The levels of protein expression for transforming growth factor-beta, focal adhesion kinase, and protein kinase B were higher in group B compared to group A, whereas the levels of protein expression for transforming growth factor-beta, focal adhesion kinase, and protein kinase B were lower in group C compared to group B. The non-small cell lung cancer is influenced by astragaloside A, transforming growth factor-beta, focal adhesion kinase, and protein kinase B.
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