All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis, structure activity relationship studies and pharmacological evaluation of 2-phenyl-3-(substituted phenyl)-3h-quinazolin-4-ones as serotonin 5-ht 2 antagonists

Author(s): N Sati1, S Kumar2, M. S. M Rawat3
1 Department of Pharmaceutical Sciences, H. N. B. Garhwal University, Srinagar Garhwal-246 174, India 2 College of Pharmacy, IFTM, Lodipur-Raipur, Delhi Road, Moradabad-244 001, India 3 Department of Chemistry, H. N. B. Garhwal University, Srinagar Garhwal-246 174, India

Correspondence Address:
N Sati Department of Pharmaceutical Sciences, H. N. B. Garhwal University, Srinagar Garhwal-246 174 India satinitin@yahoo.co.in


Benzoyl chloride was added to the solution of anthranilic acid in pyridine to afford crude 2-phenyl-benzo[d][1, 3] oxazin-4-one (1). To the solution of compound 1 in dry toluene, various substituted anilines were added and the mixture refluxed for 8 h to afford 2-phenyl-3-(substituted phenyl)-3H-quinazolin-4-ones (2a-2f). All the compounds were obtained in solid state in yields varying between 40 to 70%. Spectral characterization included FTIR, 1 H NMR and Electrospray MS. The synthesized compounds were screened for 5-HT 2 antagonist activity. Some of the title compounds have been found to show significant 5-HT 2 antagonist activity. The compound 2b, 3-(2-chlorophenyl)-2-phenyl-3H-quinazolin-4-one was the most potent derivative in the series of compound synthesized.

Full-Text | PDF

 
 
Google scholar citation report
Citations : 69022

Indian Journal of Pharmaceutical Sciences received 69022 citations as per google scholar report