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Abstract
Synthesis, Spectral Characterization and Antimicrobial Studies of New Hybrid Heterocyclic Compounds Bearing 1H-benzimidazol-2-yl Thiomethyl Motif
Author(s): S. R. Deshpande*, P. S. Chavan, S. N. Nagarale and M. V. Patil
Division of Medicinal and Pharmaceutical Chemistry, HSK College of Pharmacy, BVVS Old Campus, Bagalkot-587 101, India
Correspondence Address:
Division of Medicinal and Pharmaceutical Chemistry, HSK College of Pharmacy, BVVS Old Campus, Bagalkot-587 101, India E-mail: srinidesh71@gmail.com
Division of Medicinal and Pharmaceutical Chemistry, HSK College of Pharmacy, BVVS Old Campus, Bagalkot-587 101, India
Correspondence Address:
Division of Medicinal and Pharmaceutical Chemistry, HSK College of Pharmacy, BVVS Old Campus, Bagalkot-587 101, India E-mail: srinidesh71@gmail.com
To understand the biological importance of heterocyclic cores, novel 1H-benzimidazol-2-yl thiomethyl incorporated hybrid compounds, 2-(benzimidazol-2-ylthiomethyl)-5-aryl-1,3,4-oxadizoles and 1-(2-(1H-benzo[d]imidazol-2-ylthio)acetyl)pyridazine/phthalazinediones were designed using molecular hybridization technique, synthesized and characterized. The compounds were screened for in vitro antimicrobial activity using the serial dilution technique and were found to exhibit weak antitubercular activity, excellent to moderate antibacterial and better antifungal activities against some tested organisms in comparison to the standard drugs. Thus, some of the title compounds demonstrated antimicrobial activity.
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