All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis of "1-2'-(5'-alkyl-1',3,4'-thiadiazolyl)-2-methyl-4-(2"-phenyl-indole-3"- yl)-methylene-imidazole-5-ones" as CVS, CNS and anti-inflammatory agents.

Author(s): R Singh, VK Pandey, RC Srimal
Dept. of Chemistry, Lucknow University, Lucknow-226 007,

Correspondence Address:
R Singh Dept. of Chemistry, Lucknow University, Lucknow-226 007

Condensation of phenyl hydrazine with acetophenone gives acetophenone phenyl hydrazone (I) which cyclises to 2-phenyl-indole (II) in the presence of anhydrous ZnCl2. Interaction of (II) with phosphorous oxychloride in DMF solvent affords 2-phenyl-indole-3-aldehyde (III). The reaction of (III) with acetic anhydride in the presence of sodium acetate furnishes 2-methyl-4-(2'-phenyl-indole-3'-yl)-methylene oxazole-5-one (IV). Condensation of (IV) with 2-amino 5-alkyl, 1,3,4-thiadiazoles affords 1-2'-5(5(-alkyl-1',3',4'-thiadiazolyl) -2-methyl-4-(2"-phenyl-indole-3'-yl-methylene-imidazole-5-ones. Some of the compounds show promising CNS, CVS and anti-inflammatory properties. The present paper describes the synthesis along the following route.

PDF

 
 
Google scholar citation report
Citations : 69022

Indian Journal of Pharmaceutical Sciences received 69022 citations as per google scholar report