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Abstract
Synthesis, Characterization and Antitumour Activity of Some Novel Oxazine Substituted 9-Anilinoacridines and their 3D-QSAR Studies
Author(s): R. Kalirajan*, V. Kulshrestha and S. Sankar
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Udhagamandalam-643 001, India
Correspondence Address:
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Udhagamandalam-643 001, India, E-mail: rkalirajan@ymail.com
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Udhagamandalam-643 001, India
Correspondence Address:
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Udhagamandalam-643 001, India, E-mail: rkalirajan@ymail.com
A series of oxazine substituted 9-anilinoacridines were synthesized, characterized, and evaluated for antitumor activity against Daltons lymphoma ascites cells using in vitro and in vivo methods. Results indicated that these conjugates exhibited significant antitumour activity on Daltons lymphoma ascites cells. Among these agents, compounds 4b, 4c, 4e and 4j were the most cytotoxic with CTC50 value of 96.5-190 µg/ml (0.125-0.352 µM). 3D QSAR study was performed using PHASE module of Schrodinger suite.
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