Synthesis, antiviral and cytotoxic activities of 2-(2-Phenyl carboxylic acid)-3-Phenylquinazolin -4(3H)-one derivatives

P Selvam1; N Murugesh2; M Ch; ramohan3; C Pannecouque4; E DE Clercq4

doi:10.4103/0250-474X.84603

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Abstract

Synthesis, antiviral and cytotoxic activities of 2-(2-Phenyl carboxylic acid)-3-Phenylquinazolin -4(3H)-one derivatives

Author(s): P Selvam¹, N Murugesh², M Chandramohan³, C Pannecouque4, E DE Clercq⁴
¹Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malapuram - 673 436, India ²Institute of Pharmacology, Madurai Medical College, Madurai - 625 001, India ³Bharat Ratna Kamarajar Liver Hospital and Research Centre, Madurai - 625 001, India ⁴Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, Leuven B - 3000, Belgium

Correspondence Address:
P Selvam Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malapuram - 673 436 India E-mail: periyasamy_selvam@yahoo.co.in

DOI: 10.4103/0250-474X.84603

A series of novel 2,3-disubstitutedquinazolin-4(3H)-ones have been synthesized by condensation of 2-substituted benzo[1,3]oxazine-4-ones and anthranilic acid. Synthesized compounds were evaluated for in vitro antiviral activity against HIV, HSV and vaccinia viruses. 5-Bromo-2-(6-bromo-4-oxo-2-phenyl-4H-quinazolin-3-yl)-benzoic acid (MBR2) exhibited distinct antiviral activity against Herpes simplex and vaccinia viruses.

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