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Abstract
Synthesis, Antibacterial And AntiHIV Activities Of 3-(5-Amino-6-(2-3-Dichloro-Phenyl)-(1,2,4) Triazin-3-Yl)-6,8-Dibromo-2-Substituted-3H-Quinozolin-4-One
Author(s): P Selvam, K Girija, G Nagarajan, E De Clercq
A series of novel 2,3-disubstituted/6,8-dibromo-2,3-disubstituted quinazolin-4(3H)-ones have been synthesized by condensing the primary amino group of lamotrigine with benzoxazin-4-one.The structure of the synthesised compounds was elucidated by spectral analysis (IR, NMR and Mass). The compounds synthesized were screened for antibacterial and antiHlV activities against replication of HIV-1 and HIV-2 in acutely infected LIT-4 cells. The compounds SPC-I, SPC-I Brand SPCIII Br (100 μg/ml) exhibited equivalent antibacterial activity with the standard ciprofloxacin (10 μg/ ml) against salmonella typhi. All the compounds exhibited cytotoxic properties in the MT-4 lymphocyte cell line.
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