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Abstract
Synthesis And Pharmacological Evaluation Of 1-[2,6,8-Trisubstituted ???4(3H)-Oxoquinazolin-3-Yl]-3-(4-Substituted Phenyl) Thiobarbiturates
Author(s): G. V. S Rama Sarma, J Vekateswara Rao, B Suresh
Twelve new 1-[2,6,8-trisubstituted-4(3H)-oxoquinazolin-3-yl]-3-(4-substituted phenyl) thiobarbiturates (17-28) were synthesized by reacting 2, 6,8-trisubstituted-3-[N3-(4-substituted phenyl) thioureido]-4(3H)-quinazolones (5-1 6) with malonic acid in presence of acetyl chloride. These thioureidoquinazolone intermediates were obtained, on the other hand, by the condensation of 3-amino-2,6,8-trisubstituted-4(3H)- quinazolones (1-4) with different 4-substituted phenyl isothiocyanates. All these compounds were characterized by analytical and spectral data. Compounds 27, 24 and 20 were found to possess good sedative properties while compounds 18, 26 and 28 exhibited significant anticonvulsant activity.
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