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Abstract
Synthesis and pharmacological activities of 2-methyl-8-quinolyloxypropylamines
Author(s): YSR Reddy1, MD. Afzal Azam2, JT Leonard2, B Suresh2, IE Chakravarthy3
1 G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-500 028, India 2 J. S. S. College of Pharmacy, Rockland's, Ootacamund-643 001, India 3 Department of Chemistry, S. K. U. P. G. Center, Kurnool-518 002, India
Correspondence Address:
YSR Reddy G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-500 028 India
1 G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-500 028, India 2 J. S. S. College of Pharmacy, Rockland's, Ootacamund-643 001, India 3 Department of Chemistry, S. K. U. P. G. Center, Kurnool-518 002, India
Correspondence Address:
YSR Reddy G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-500 028 India
Starting chloropropane derivative (2) was prepared by the reaction of 2-methyl-8-hydroxyquinoline (1) with 1- bromo-3-chloropropane in presence of a base. Various new 1-(2-methyl-8-quinolyloxy)-3-propylamines (3a-3j) have been synthesized by the condensation of 1-(2-methyl-8-quinolyloxy)-3-chloropropane (2) with different amines. Compounds were screened for the possible central nervous system depressant activities. Some of them showed moderate central nervous system depressant activity.
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