All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Abstract
Synthesis and evaluation of novel benzothiazole derivatives against human cervical cancer cell lines
Author(s): Suvarna Kini, SP Swain, AM Gandhi
Dept. of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, MAHE, Manipal-576 104, India
Correspondence Address:
Suvarna Kini Dept. of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, MAHE, Manipal-576 104 India E-mail: suvarna.gk@manipal.edu
Dept. of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, MAHE, Manipal-576 104, India
Correspondence Address:
Suvarna Kini Dept. of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, MAHE, Manipal-576 104 India E-mail: suvarna.gk@manipal.edu
The 2-arylsubstituted benzothiazole derivatives were synthesized by refluxing o-aminothiophenol with substituted benzoic acids in the presence of polyphosphoric acid at 220°. 2-Mercaptothiazole was used along with thionyl chloride to get the carbothioates. The physical and spectral data such as mp, Rf, IR, NMR was obtained for the synthesized compounds and the structures were confirmed. The screening for antitumour activity was done as per the National Cancer Institute drug screening strategy 3 compounds were found to be significantly cytotoxic as compared to [2-(3-bromo-4-aminophenyl) benzothiazole] against the human cervical cancer cell lines.
indian sex, xnxx hd, telugu porn stars, indian village wife early morning sex, desi xxx, desi saree draping
Full-Text | PDF