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Abstract
Synthesis And Evaluation Of Clenbuterol/Rimiterol Analogues
Author(s): Amar R Mandawade, Reshma G Wadke, C. L Viswanthan
Two compounds were synthesised by combining the structural features of bronchodilators Clenbuterol and Rimiterol. Two clenbuterol analogues with only one chlorine atom on aromatic nucleus were synthesised to ascertain whether activity is retained and also to establish a new route of synthesis. All compounds were tested for smooth muscle relaxant property in different test systems and one of them exhibited bronchodilator activity comparable to that of isoproterenol.
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