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Abstract
Synthesis and Cytotoxicity Evaluation of Unusual Mixture Acid Acetate-protected Monogalactosyldiacylglycerols
Author(s): S. Vudhgiri, D. Koude12, S. Misra12, R. B. N. Prasad2 and R. C. R. Jala2*
Centre for Lipid Research, 1Pharmacology and Toxicology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500 007, 2Academy of Scientific and Innovative Research, Ghaziabad-201 002, India
Correspondence Address:
Academy of Scientific and Innovative Research, Ghaziabad-201 002, India, E-mail: jrcreddy10@gmail.com, ramchandra@iict.res.in
Centre for Lipid Research, 1Pharmacology and Toxicology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500 007, 2Academy of Scientific and Innovative Research, Ghaziabad-201 002, India
Correspondence Address:
Academy of Scientific and Innovative Research, Ghaziabad-201 002, India, E-mail: jrcreddy10@gmail.com, ramchandra@iict.res.in
In the present study, acetate-protected monogalactosyldiacylglycerol and its fatty acid and aromatic acid analogues were synthesized using trichloroacetimidate methodology. All compounds synthesized were evaluated for cytotoxicity against four cancer cell lines and one normal cell line. Among the compounds tested, mixed acid compound 7b exhibited good activity with IC50 value of 27.5 μM. In a similar manner, the combination of unsaturated oleic acid and cinnamic acid compound 7d also exhibited significant activity with IC50 value 34.9 μM. Based on these results, it could be concluded that the combination of oleic acid with cinnamic acid type acid and other saturated fatty acids enhance the cytotoxicity of glycoglycerolipids.
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