Abstract
Synthesis and Characterization of Mutual Prodrugs of Ofloxacin (4-Flouroquinolone) with Non-Steroidal Anti-Inflammatory Drugs
Department of Chemistry, Gurugram University, Gurugram, Haryana 122003, India
Correspondence Address:
Arshi Hussain, Department of Chemistry, Gurugram University, Gurugram, Haryana 122003, India, E-mail: hussis786@gmail.com
The aim of this study was to develop an efficient and safer drug for targeted drug delivery mutual prodrugs of an antibacterial-ofloxacin with paracetamol and salicylic acid were synthesized that could be used for the management of intestinal bowel diseases like ulcerative colitis, Crohn’s disease, colon cancer etc. Ester-based mutual prodrugs of ofloxacin with paracetamol and salicylic acid were synthesized using better coupling approach in which 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride was used as a coupling reagent. Based on ultraviolet, infrared, 1H nuclear magnetic resonance, 13C nuclear magnetic resonance and mass spectroscopy, their structures were analyzed and confirmed. These prodrugs may be used with the intention of treating both inflammation and infection simultaneously in targeted drug delivery system.
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