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Abstract
Synthesis and biological evaluation of 4,6-diaryl substituted-4,5-dihydro-2-amino pyrimidines
Author(s): J Venkatesan1, SN Pandeya2, D Selvakumar3
1 Department of Pharmaceutics, Birla Institute of Technology, Mesra, Ranchi, India 2 Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi - 221 005, India 3 Department of Pharmaceutical Chemistry, SB College of Pharmacy, Anaikuttam, Sivakasi - 626 130, India
Correspondence Address:
D Selvakumar Department of Pharmaceutical Chemistry, SB College of Pharmacy, Anaikuttam, Sivakasi - 626 130 India E-mail: deselva123@rediffmail.com
1 Department of Pharmaceutics, Birla Institute of Technology, Mesra, Ranchi, India 2 Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi - 221 005, India 3 Department of Pharmaceutical Chemistry, SB College of Pharmacy, Anaikuttam, Sivakasi - 626 130, India
Correspondence Address:
D Selvakumar Department of Pharmaceutical Chemistry, SB College of Pharmacy, Anaikuttam, Sivakasi - 626 130 India E-mail: deselva123@rediffmail.com
4,6-Diaryl substituted-4,5-dihydro-2-amino pyrimidines have been synthesized by the reaction of chalcones with guanidine nitrate. Their chemical structures have been confirmed by means of IR and NMR data and by elemental analysis. The compounds were screened for antibacterial activity against 16 gram-positive bacterial strains in minimum inhibitory concentration. The minimum inhibitory concentration of the compound II has found to be better than the reference standards taken for the antibacterial screening. Sulphamethoxazole and trimethoprim were taken as reference standards.
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