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Abstract
Synthesis And Biological Activity Of Some Amino Acid Conjugates Of Oxaprozin
Author(s): S. J Kachhwaha, Sheeba Varghese, D Gupta, Deepali Mhaske, S. R Dhaneshwar
Amino acid conjugates between various amino acid methyl esters and the carboxylic acid group of oxaprozin were synthesized using N,N’-dicyclohexylcarbodiimide as a coupling agent. These compounds were characterized by analytical and spectral data. Kinetics of hydrolysis of these conjugates was studied. The esters were evaluated for analgesic and antiinflammatory activity and ulcerogenicity. The esters showed comparable analgesic and anti-inflammatory activity with negligible ulcerogenicity.
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