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Abstract
Synthesis and biological activities of some benzimidazolone derivatives
Author(s): BK Karale1, SS Rindhe2, MA Rode2
1Department of Chemistry, Radhabai Kale Mahila Mahavidyalaya, Ahmednagar-414 001, India 2Department of Chemistry, New Arts, Commerce and Science College, Ahmednagar-414 001, India
Correspondence Address:
M A Rode Department of Chemistry, New Arts, Commerce and Science College, Ahmednagar-414 001 India E-mail: milindrode@yahoo.com
1Department of Chemistry, Radhabai Kale Mahila Mahavidyalaya, Ahmednagar-414 001, India 2Department of Chemistry, New Arts, Commerce and Science College, Ahmednagar-414 001, India
Correspondence Address:
M A Rode Department of Chemistry, New Arts, Commerce and Science College, Ahmednagar-414 001 India E-mail: milindrode@yahoo.com
The reaction of 5-nitrobenzimidazolone with phenoxyethyl bromide in presence of potassium carbonate in dimethyl formamide obtained 6-nitro-1,3-bis(2-phenoxyethyl)-1,3-dihydro-2H-benzimidazol-2-one. It was reduced using stannous chloride to get 6-amino -1,3-bis(2-phenoxyethyl)-1, 3-dihydro-2H-benzimidazol -2-one, which was further treated with aromatic sulphonyl chloride to obtain benzimidazolone derivatives, 6a-k. These compounds were tested for antibacterial, antituberculosis and antifungal activity. Most of them have shown very good activity against some gram positive and gram negative microorganisms and fungal strains. Some of them have shown moderate activity against Mycobacterium tuberculosis.
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