Abstract
Synthesis And Antimicrobial Activity Of Phthalimido (2-Aryl-3-Isonicotinamido-4-Oxo-1, 3-Thiazolidine-5-yl) Ethanoates
2-Aryl-3-isonicotinamido-4-oxo-1,3-thiazolidine-5-yl ethanoic acid (2a-h) have been synthesized via cycloaddition of 4-arylidenehydrazido pyridine (1a-h) with mercaptosuccinic acid in THF containing a pinch of ZnCI2, which on treatment with thionyl chloride give corresponding ethanoyl chloride derivatives (3a-h).These on treatment with N-hydroxyphthalimide afford titled compounds (4a-h). IR, 1H NMR, Mass and 13C NMR determined their structures. All the synthesized compounds were screened for antibacterial (Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Pseudomonas aeruginosa and Salmonella typhi) and antifungal (Candida albicans and Aspergillus fumigatus) activities. All the compounds exhibited significant activity against the bacteria and fungl tested.
