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Abstract
Synthesis And Antiinflammatory Activity Of Aryl Sulphonanilides Structurally Related To Nimesulide
Author(s): Vinayata Attal, D.P Belsare
Substituted sulphonanilides of diphenyl ether, benzyl phenyl ether and diphenylamine were synthesized which were structurally related to antiinflammatory drug nimesulide. Synthesized compounds displayed antiinflammatory activity comparable with that of nimesulide. From the result it can be concluded that the replacement of methane sulphonanilide group with other sulphonanilide and replacement of ether oxygen with -OCH2-,-NH- decreases activity.
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