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Abstract
Synthesis And Antiinflammatory Activity Of Aminomethylisoxazolinyl/Azopyrazolinyl Diphenylamine Derivatives
Author(s): P Rani, V. K Srivastava, A Kumar
Chalcones (2-5), isoxazolines (6-9), Mannich bases (10-25), pyrazolines (26-29) and azo derivatives (30'-33) of diphenylamine were synthesized and screened against carrageenan-induced edema in rats at 50 mg/kg, orally. All the compounds of this series have shown promising anti-inflammatory activity. Compound (29) [1-acetyl-5-(4-methoxypheny1)-2-pyrazoliny diphenylamine was found to be the most potent, even more that the standard, phenylbutazone. This compound was also evaluated for ulcerogenicity and acute toxicity.
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