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Abstract
Synthesis and anti-inflammatory activities of some n-acetyl-2-phenylindole mannich bases.
Author(s): SR Dhaneshwar, SC Chaturvedi, Christiana
College of Pharmacy, S.G.S.I.T.S. Campus, Indore-452 003,
Correspondence Address:
S R Dhaneshwar College of Pharmacy, S.G.S.I.T.S. Campus, Indore-452 003
College of Pharmacy, S.G.S.I.T.S. Campus, Indore-452 003,
Correspondence Address:
S R Dhaneshwar College of Pharmacy, S.G.S.I.T.S. Campus, Indore-452 003
Mannich bases of N-acetyl-2-phenylindole were synthesized using different secondary amines. The formation of the products was confirmed by analytical and spectral data. Anti-inflammatory activities of the synthesized compounds were evaluated by carrageenan induced eodema of the rat paw method. All the compounds tested,showed fairly greater activity than the parent compound at a dose level of 100 mg/kg. Compound 3-(pyrrolidinomethyl)N-acetyl-2-phenyylindole showed greater activity in comparision to phenylbutazone.
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