Abstract
Study on the Decrease in Neuronal Autophagy/Apoptosis by Fuyuan Xingnao Decoction in Rats with Cerebral Hemorrhage
Department of Medicine, Institute of Integrated Chinese and Western Medicine, Southwest Medical University, Sichuan, Luzhou 646099, 1Department of Neurology, National Traditional Chinese Medicine Clinical Research Base, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Sichuan, Luzhou 646610, 2Emergency Department, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, Xuhui 200032, China
Correspondence Address:
Bangjiang Fang, Emergency Department, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, Xuhui 200032, China, E-mail: fangbji@163.com
The objective of this study was to investigate the effects of autophagy/apoptosis on neurons following cerebral hemorrhage in rats, specifically focusing on the regulation of B cell lymphoma-2 on B cell lymphoma-2 associated X, beclin-1 and the regulatory mechanism of autophagy/apoptosis by Fuyuan Xingnao decoction. Rapamycin and Fuyuan Xingnao decoction were used to treat neurons in rats that had cerebral hemorrhage as well as neurons that mimicked it; autophagy is agonistic to rapamycin. Following 3 d of brain bleeding, there was an increase in both autophagy and apoptosis. When rats with cerebral hemorrhage were given Fuyuan Xingnao decoction, autophagy and apoptosis increased and the neurological impairments were decreased. In contrast, rapamycin boosted these processes in the same animals. Fuyuan Xingnao decoction can preserve neurons in rats suffering from cerebral hemorrhage, decrease autophagy and apoptosis following cerebral hemorrhage thereby ameliorating the neurological impairments.
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