All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Studies on 2-azetidinone : part -vi synthesis and antimicrobial activity of 5-(2', 4'-dichloro phenoxy methyl)-2-(4"-aryl-3"-chloro-2"-azetidinone-1"-yl)-1,3,4-thiadiazole.

Author(s): K DEsai, AJ Baxi
Department of Chemistry, Saurashtra University, RAJKOT- 360 005,

Correspondence Address:
K DEsai Department of Chemistry, Saurashtra University, RAJKOT- 360 005

Some 2-azetidinone derivatives bearing 1,3,4-thiadiazole moiety have been synthesised by treating thiosemicarbazide with 2,4-dichlorophenoxy acetic acid in presence of phosphorus oxychloride, which resulted in product-1. This on treatment with aromatic aldehydes gave schiff's bases of thiadiazoles, product-II, which on further reaction with chloroacetyl chloride yielded the desired product (1 to 10 and 11 to 20). the structure of the products have been established by elemental analyses and spectral study. All the compounds have been evaluated for their antimicrobial activity against different microorganisms.

PDF

 
 
Google scholar citation report
Citations : 69022

Indian Journal of Pharmaceutical Sciences received 69022 citations as per google scholar report