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Abstract
Strategies for enhanced drug delivery to the central nervous system
Author(s): V.S.N.M Dwibhashyam1, AN Nagappa2
1TherDose Pharma (P) Ltd., Plot No: 30-32, Survey No. 400, Prasanth Nagar, IE, Hyderabad-500 072, India 2Department of Pharmacy Practice, 4th Floor, Shirdi Sai Baba Cancer Hospital, Manipal-576 104, India
Correspondence Address:
A N Nagappa Department of Pharmacy Practice, 4th Floor, Shirdi Sai Baba Cancer Hospital, Manipal-576 104 India E-mail: anantha1232000@gmail.com
1TherDose Pharma (P) Ltd., Plot No: 30-32, Survey No. 400, Prasanth Nagar, IE, Hyderabad-500 072, India 2Department of Pharmacy Practice, 4th Floor, Shirdi Sai Baba Cancer Hospital, Manipal-576 104, India
Correspondence Address:
A N Nagappa Department of Pharmacy Practice, 4th Floor, Shirdi Sai Baba Cancer Hospital, Manipal-576 104 India E-mail: anantha1232000@gmail.com
Treating central nervous system diseases is very challenging because of the presence of a variety of formidable obstacles that impede drug delivery. Physiological barriers like the blood-brain barrier and blood-cerebrospinal fluid barrier as well as various efflux transporter proteins make the entry of drugs into the central nervous system very difficult. The present review provides a brief account of the blood brain barrier, the P-glycoprotein efflux and various strategies for enhancing drug delivery to the central nervous system.
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