All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Stability-indicating RP-HPLC method for estimation of miglitol in bulk and tablets

Author(s): B Shrivastava1, US Baghel1, M Sahu2
1School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur-302 025, India 2Torent Pharmaceutical Pvt. Ltd., Ahmadabad, 380 009, India

Correspondence Address:
U S Baghel School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur-302 025 India E-mail: uttamsinghbaghel@yahoo.co.in


A selective and sensitive, stability-indicating reverse phase high performance liquid chromatography method has been first developed and validated for the estimation of miglitol in bulk and tablet dosages form. Samples were separated on a prepacked, Inertsil amino C 18 column (150Χ4.6 mm i.d.) using a mobile phase comprised of acetonitrile and monobasic sodium phosphate pH 7.5 (80:20, v/v) delivered at 1.5 ml/min flow rate. Detection was performed on a SPD-20A prominence UV/Vis detector at 220 nm. The retention time for miglitol was 13.93±0.0367. The method was validated in terms of linearity, precision, accuracy, ruggedness, and specificity, limit of detection and limit of quantification. The linearity (r 2 ) and percentage recoveries of miglitol were 0.9986 and 99.85%. This method is suitable for routine estimation of miglitol in bulk and tablet dosages form.

Full-Text | PDF

 
 
Google scholar citation report
Citations : 69022

Indian Journal of Pharmaceutical Sciences received 69022 citations as per google scholar report