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Abstract
Spectrophotometric method for the estimation of Oxcarbazepine in tablets
Author(s): CS Ramaa, PP Chothe, AA Naik, VJ Kadam
Department of Quality Assurance, Bharati Vidyapeeth's College of Pharmacy, Sector-8, CBD, Navi Mumbai- 400 614, India
Correspondence Address:
C S Ramaa Department of Quality Assurance, Bharati Vidyapeeth's College of Pharmacy, Sector-8, CBD, Navi Mumbai- 400 614 India E-mail: sinha_ramaa@hotmail.com
Department of Quality Assurance, Bharati Vidyapeeth's College of Pharmacy, Sector-8, CBD, Navi Mumbai- 400 614, India
Correspondence Address:
C S Ramaa Department of Quality Assurance, Bharati Vidyapeeth's College of Pharmacy, Sector-8, CBD, Navi Mumbai- 400 614 India E-mail: sinha_ramaa@hotmail.com
The objective of this work was to develop a simple, accurate, rapid and sensitive method for the estimation of oxcarbazepine in tablets. The estimation is based on the reduction of ferric ions in its salt form to ferrous ions by the drug, which in presence of potassium ferricyanide produces green colored chromogen measured at 770 nm against reagent blank. The chromogen obeyed linearity over 4 to 28 mg/ml (r=0.9981) with percent relative standard deviation (% RSD) of 0.4267. Recovery studies gave values ranging between 98.26 and 98.76. The proposed method is simple and suitable for routine determination of oxcarbazepine in tablets.
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