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Abstract
Spectrophotometric estimation of risperidone in tablets
Author(s): BK Jayanna, TD Devaraj, KP Roopa, G Nagendrappa, HR Arun Kumar, N Gowda
Department of Chemistry, B. N. M. Institute of Technology, Bengaluru-560 070, India
Correspondence Address:
B K Jayanna Department of Chemistry, B. N. M. Institute of Technology, Bengaluru-560 070 India E-mail: jay_bidarur@yahoo.co.in
Department of Chemistry, B. N. M. Institute of Technology, Bengaluru-560 070, India
Correspondence Address:
B K Jayanna Department of Chemistry, B. N. M. Institute of Technology, Bengaluru-560 070 India E-mail: jay_bidarur@yahoo.co.in
A simple, rapid and highly sensitive spectrophotometric method is developed for the determination of risperidone in tablet formulation. The method is based on the oxidation of drug using potassium permanganate in alkaline medium and excess potassium permanganate oxidizes 1,10-phenanthroline Fe(II). The measurement of decrease in absorbance of 1,10-phenanthroline Fe (II) was done at 415 nm. The beer's law is obeyed in the concentration range of 5.0 to 40.0 μg/ml and molar absorptivity is found to be 7.3932 × 10 4 l/mol/cm. The proposed method is well suited for the pharmaceutical formulations.
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