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Abstract
Spectrophotometric estimation of ketotifen fumarate from tablet formulations
Author(s): I Singhvi1, D Sachdeva2
1 Pacific College of Pharmacy, Pacific Hills, Pratap Nagar, Air-port Road, Udaipur-313 001, India 2 Sanjeevan College of Pharmacy, Dausa-303 303, India
Correspondence Address:
I Singhvi Pacific College of Pharmacy, Pacific Hills, Pratap Nagar, Air-port Road, Udaipur-313 001 India indrajeetsinghvi@yahoo.com
1 Pacific College of Pharmacy, Pacific Hills, Pratap Nagar, Air-port Road, Udaipur-313 001, India 2 Sanjeevan College of Pharmacy, Dausa-303 303, India
Correspondence Address:
I Singhvi Pacific College of Pharmacy, Pacific Hills, Pratap Nagar, Air-port Road, Udaipur-313 001 India indrajeetsinghvi@yahoo.com
Two simple and sensitive visible spectrophotometric methods have been developed for the quantitative estimation of ketotifen fumarate from its tablet formulation. The developed methods are based on formation of chloroform extractable colored complex of with 2-nitroso- napthol-4- sulphonic acid and rhodizonic acid. The extracted complex of drug with 2-nitroso- napthol-4- sulphonic acid (method-I), showed absorbance maxima at 436.5 nm and with rhodizonic acid (method-II), showed absorbance maxima at 489.5 nm. The linearity range for both the developed methods was observed in the concentration range of 50-250 µg/ml of drug. Results of analysis for both the developed methods were validated statistically and by recovery studies.
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