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Abstract
Spectrophotometric Determination Of Indinavir With Precipitation Reagents
Author(s): C. S. N Sarma, C Kamala Sastri, C. S. P Sastry
Indinavir sulphate forms insoluble molecular complex with ammonium molybdate (method A), phosphomoiybdic acid (method B) or tannic acid (method C) under acid conditions. In addition, colour reactions have been combined to estimate each precipitant and in turn indinavir sulphate. They are based on the colour formation with released precipitant from the precipitate with chromogenic reagents such as potassium thiocyanate (λmax 480 nm for method A) or cobalt nitrate ethylene diamine tetra acetic acid disodium salt complex (λmax 840 nm for method B) or metolchromium (VI) (λmax 590 nm for method C). The methods are statistically validated and found to be precise and accurate.
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