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Abstract
Spectrofluorimetric method for determination of duloxetine hydrochloride in bulk and pharmaceutical dosage forms
Author(s): SL Prabhu2, S Shahnawaz2, C Dinesh Kumar2, A Shirwaikar2
2Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India 2Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India 2Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India
Correspondence Address:
S L Prabhu Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal-576 104 India E-mail: slaxmanvel@yahoo.com
2Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India 2Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India 2Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India
Correspondence Address:
S L Prabhu Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal-576 104 India E-mail: slaxmanvel@yahoo.com
A simple accurate, sensitive and reproducible spectrofluorimetric method was developed for the analysis of duloxetine hydrochloride in pure and pharmaceutical dosage form. Duloxetine hydrochloride showed strong native fluorescence in 0.05 M acetic acid having excitation at 225 nm and emission at 340 nm. Effect of different solvents were thoroughly investigated. The calibration graph was linear in the range from 0.020 to 0.400 µg/ml. The proposed method was statistically validated and successfully applied for analysis of capsule dosage forms. The limit of detection and limit of quantification were found to be 0.003 µg/ml and 0.010 µg/ml, respectively. The percentage recovery was found to be in the range of 98.71% to 99.17%.
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