Abstract

Migraine is a common disabling brain dysfunction disease. Increasing evidence shows that the braingut axis can regulate brain dysfunction disease. However, the mechanism of interaction between the gut and brain in migraine patients is still unclear. In this study, we evaluated the effect of sodium propionate treatment on intestinal microbiota, metabolites and pain behavior of the migraine model induced by inflammation soup in rats. We administered 100 mg/kg sodium propionate to rats by gavage, placed a catheter on the dura mater and stimulated them with chronic inflammation decoction. Migraine-like headache was evaluated by behavioral tests. The rat feces were extracted for microbial community and metabolic pathway analysis. Our results show that sodium propionate treatment can help rats with inflammation decoction sodium propionate induced facial hyperalgesia, and inflammation decoction sodium propionate induced pain stimulation can make the body produce higher levels of some tryptophan metabolites to fight pain and sodium propionate treatment will restore the metabolites to normal levels. These results indicate that sodium propionate alleviates inflammation decoction sodium propionate induced migraine-like headaches and intestinal metabolic disorders by regulating the changes in intestinal bacterial community composition and metabolites, and short-chain fatty acids may play an important role in the regulation and prevention of migraine in the future.