Abstract
Slack Pathway Deletion Mediates Gamma-Aminobutyric Acid Type A Receptor Reduction in the Effect of Propofol and Isoflurane General Anesthesia in Rats
Department of Anesthesiology, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province 215200, China
Correspondence Address:
Hui Li, Department of Anesthesiology, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province 215200, China, E-mail: lihuibbbiiigggaaa@126.com
This paper studies the effect and mechanism of Slack channel deficiency leading to gamma-aminobutyric acid type A receptor reduction on the general anesthesia effect of isoflurane and propofol. The experimental results show that Slack gene knockout mice have reduced sensitivity to isoflurane and propofol, prolonged anesthesia induction period, shortened anesthesia duration, decreased anesthesia depth, and weakened postoperative sedation effect. Slack gene knockout mice have increased levels of adrenaline and noradrenaline during anesthesia, and decreased transcription and expression levels of gamma-aminobutyric acid type A receptors. This paper provides reference for the applicability and dosage of anesthesia scheme for patients with epilepsy or other abnormal neural activities undergoing anesthesia treatment.
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