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Abstract

Simultaneous Voltammetric Determination of Nitazoxanide and Ofloxacin in Pharmaceutical Formulation

Author(s): Shital Gandhi, V Mehta, Sadhana Rajput

A simple, sensitive and highly selective electrochemical method was developed for the simultaneous determination of nitazoxanide and ofloxacin in aqueous media (Britton-Robinson buffer, pH-8.36) on a hanging mercury drop electrode (HMDE) using differential pulse polarography (DPP). Using DPP a separation of about 936 mV between the peak oxidation potentials of nitazoxanide and ofloxacin present in binary mixtures was obtained. The quantification limits for the simultaneous determination of nitazoxanide and ofloxacin were 0.083 μg/ml and 0.208 μg/ml, respectively. The proposed method was successfully applied for the simultaneous determination of nitazoxanide and ofloxacin in bulk drug and pharmaceutical tablet formulation.

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Citations : 69022

Indian Journal of Pharmaceutical Sciences received 69022 citations as per google scholar report