Simultaneous UV spectrophotometric estimation of ambroxol hydrochloride and levocetirizine dihydrochloride

S Lakshmana Prabu1; AA Shirwaikar2; Annie Shirwaikar3; C Dinesh Kumar3; G Aravind Kumar2

doi:10.4103/0250-474X.41464

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Abstract

Simultaneous UV spectrophotometric estimation of ambroxol hydrochloride and levocetirizine dihydrochloride

Author(s): S Lakshmana Prabu¹, AA Shirwaikar², Annie Shirwaikar³, C Dinesh Kumar³, G Aravind Kumar²
¹Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India ²Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India ³Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India

Correspondence Address:
A A Shirwaikar Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal-576 104 India E-mail: arunshirwaikar@yahoo.co.in

DOI: 10.4103/0250-474X.41464

A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of ambroxol hydrochloride and levocetirizine dihydrochloride. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths 242 nm and 231 nm, the g max of ambroxol hydrochloride and levocetirizine dihydrochloride, respectively. Beer's law was obeyed in the concentration range 10-50 μg/ml and 8-24 μg/ml for ambroxol hydrochloride and levocetirizine dihydrochloride respectively. Results of the method were validated statistically and by recovery studies.

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