Abstract

Three simple, accurate, economical and reproducible spectrophotometric methods for simultaneous estimation of two-component drug mixture of rosiglitazone maleate and glimepiride in combined tablet dosage form have been developed. Developed methods are based on direct estimation of rosiglitazone maleate at 318.0 nm, as at this wavelength glimepiride has zero absorbance and hence does not interfere. For estimation of glimepiride first developed method involves formation and solving of simultaneous equation at 238.0 nm. Second developed method makes use two wavelength spectroscopy using 244.8 nm and 257.2 nm as two wavelengths. Third developed method is based on first derivative spectroscopy using 252.0 nm as zero crossing point for estimation of glimepiride. All the developed methods obey Beer's law in the concentration ranges employed for the respective methods. The results of analysis were validated statistically and by recovery studies.