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Abstract
Simultaneous spectrophotometric estimation of losartan potassium and hydrochlorothiazide from combined dosage form.
Author(s): NR Lande, BM Shetkar, SS Kadam, SR Dhaneshwar
Bharati Vidyapeeth's, Poona College of Pharmacy, Erandwane, Pune-411038
Correspondence Address:
N R Lande Bharati Vidyapeeth's, Poona College of Pharmacy, Erandwane, Pune-411038
Bharati Vidyapeeth's, Poona College of Pharmacy, Erandwane, Pune-411038
Correspondence Address:
N R Lande Bharati Vidyapeeth's, Poona College of Pharmacy, Erandwane, Pune-411038
Two simple, accurate and economical procedures for simultaneous estimation of losartan potassium and hydrochlorothiazide in two component tablet formulations have been developed. The methods employ program in the multicomponent mode of analysis of the instrument used and simultaneous equations using area under curve. In all glass double distilled water losartan potassium has an absorbance maxima at 205nm, hydrochlorothiazide has three absorbance maxima at 225, 272 and 315nm. Both the drugs obey the Beer's Law in the concentration ranges employed for these methods. The results of analysis have been validated statistically and by recovery studies.
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