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Abstract
Simultaneous spectrophotometric estimation of gatifloxacin and ornidazole in tablet dosage form
Author(s): Sonali Paramane, Lata Kothapalli, Asha Thomas, AD Deshpande
Department of Pharmaceutical Chemistry, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018, India
Correspondence Address:
Sonali Paramane Department of Pharmaceutical Chemistry, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018 India E-mail: sonalipm1@yahoo.com
Department of Pharmaceutical Chemistry, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018, India
Correspondence Address:
Sonali Paramane Department of Pharmaceutical Chemistry, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018 India E-mail: sonalipm1@yahoo.com
Three simple, accurate and economic methods multicomponent, two wavelength and simultaneous equations using area under curve have been described for the simultaneous determination of gatifloxacin and ornidazole in tablet dosage form. Gatifloxacin shows absorption maximum at 287.5 nm and ornidazole shows absorption maximum at 319.5 nm in distilled water. Beer's law was obeyed in the concentration range of 2-20 µg/ml for gatifloxacin and 10-60 µg/ml for ornidazole. The methods allow rapid analysis of binary pharmaceutical formulation with accuracy. Results of analysis for three methods were validated statistically and by recovery studies and were found satisfactory.
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