Simultaneous estimation of esomeprazole and domperidone by UV spectrophotometric method

S Lakshmana Prabu1; A Shirwaikar2; Annie Shirwaikar3; C Dinesh Kumar3; A Joseph4; R Kumar2

doi:10.4103/0250-474X.40351

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Abstract

Simultaneous estimation of esomeprazole and domperidone by UV spectrophotometric method

Author(s): S Lakshmana Prabu¹, A Shirwaikar², Annie Shirwaikar³, C Dinesh Kumar³, A Joseph⁴, R Kumar²
¹Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, India ²Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, India ³Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, India ⁴Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, India

Correspondence Address:
A Shirwaikar Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal - 576 104 India

DOI: 10.4103/0250-474X.40351

A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of esomeprazole and domperidone. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 301 nm and 284 nm, 'λ max of esomeprazole and domperidone respectively. Beer's law was obeyed in the concentration range of 5-20 µg/ml and 8-30 µg/ml for esomeprazole and domperidone respectively. The method was found to be precise, accurate, and specific. The proposed method was successfully applied to estimation of esomeprazole and domperidone in combined solid dosage form.

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