Abstract

Aneurysmal subarachnoid hemorrhage is a severe neurological disease that is characterized by acute onset, multiple complications and poor prognosis. The aim of this study was to analyze the relationship between the expression level of micro ribonucleic acid-30c in plasma and prognosis in patients with aneurysmal subarachnoid hemorrhage. A total of 181 patients with aneurysmal subarachnoid hemorrhage were prospectively selected as study subjects. Modified Rankin scale was used to evaluate the prognosis of the subjects and detecting the level of micro ribonucleic acid-30c by real-time fluorescence quantitative polymerase chain reaction to analyze the relationship between micro ribonucleic acid-30c and prognosis. The levels of micro ribonucleic acid-30c in poor prognosis group (T0-micro ribonucleic acid-30c, T1-micro ribonucleic acid-30c and T2-micro ribonucleic acid-30c) were significantly lower than those in good prognosis group (p<0.05). The logistic regression analysis showed that the T2-micro ribonucleic acid-30c was an independent protective factor for the prognosis of aneurysmal subarachnoid hemorrhage patients (p<0.05). The results of restricted cubic spline fitting logistic regression analysis showed that T2-micro ribonucleic acid-30c had a non-linear relationship with the prognosis of patients with aneurysmal subarachnoid hemorrhage. The level of micro ribonucleic acid-30c in patients with aneurysmal subarachnoid hemorrhage is closely related to their prognosis. The low level of T2-micro ribonucleic acid-30c suggested a higher risk of poor prognosis.