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Abstract

Recent Trends and Future Prospects of Phytosomes: A Concise Review

Author(s): Kalyani Sakure, Anjali Patel, Madhulika Pradhan and H. R. Badwaik*
Department of Pharmaceutics, Rungta College of Pharmaceutical Sciences and Research, Bhilai, Chhattisgarh 490024, 1Department of Pharmaceutical Chemistry, Gracious College of Pharmacy, Abhanpur, Chhattisgarh 493661, 2Department of Pharmaceutical Sciences, Shri Shankaracharya Institute of Pharmaceutical Science and Research, Bhilai, Chhattisgarh 490020, India

Correspondence Address:
H. R. Badwaik, Department of Pharmaceutical Sciences, Shri Shankaracharya Institute of Pharmaceutical Science and Research, Bhilai, Chhattisgarh 490020, India, E-mail: hemantrbadwaik@gmail.com


Phytosome is a phospholipid based well-turned, self-assembled vesicular drug delivery system. It is an advanced form of herbal preparation that includes bioactive phytoconstituents of herbal extract surrounded and tied by a lipid. The phospholipid’s molecular structure is composed of a head that is water-soluble and two tails that are fat-soluble. As a result of their dual solubility, the phospholipids function as an efficient emulsifier and act as a key component of our cell's membranes. Phytosomes are created with standardized plant extracts or phytoconstituents, such as flavonoids, terpenoids, tannins and xanthones, complexed with phospholipids like phosphatidylcholine. It exhibits significantly improved absorption profiles after oral administration due to enhanced lipid solubility that allows them to cross biological membranes, increasing their bioavailability. This article briefs about an updated overview of therapeutic potentials, patented technologies and recent formulations of phytosome drug delivery systems. The current review also highlights commercial availability, recent advanced research, and landmarks in the development of phytosomes and phytosome technology.

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