All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Abstract
Quantitative analysis of propranolol hydrochloride by high performance thin layer chromatography
Author(s): Girija Bhavar, VA Chatpalliwar
Department of Pharmaceutical Chemistry, R. C. Patel College of Pharmacy, Karvand Naka, Shirpur-425 405, India
Correspondence Address:
V A Chatpalliwar Department of Pharmaceutical Chemistry, R. C. Patel College of Pharmacy, Karvand Naka, Shirpur-425 405 India E-mail: vchatpalliwar@yahoo.co.in
Department of Pharmaceutical Chemistry, R. C. Patel College of Pharmacy, Karvand Naka, Shirpur-425 405, India
Correspondence Address:
V A Chatpalliwar Department of Pharmaceutical Chemistry, R. C. Patel College of Pharmacy, Karvand Naka, Shirpur-425 405 India E-mail: vchatpalliwar@yahoo.co.in
A simple, accurate and precise HPTLC method has been developed for estimation of propranolol hydrochloride from bulk drug and tablet formulations. The separation was achieved on TLC plates using appropriate solvent system. The spots so developed were densitometrically scanned at 290 nm. The linearity of the method was found to be within the concentration range of 200-2000 ng/spot. The validation parameters, tested in accordance with the requirements of ICH guidelines, prove the suitability of this method. The method was successively applied for determination of drug in tablets, wherein, no interference from tablet excipients was observed.
Full-Text | PDF
