Abstract
Pyridine Moiety: Recent Advances in Cancer Treatment
Department of Pharmacy, School of Medical & Allied Sciences, Galgotias University, Greater Noida 201310, 1Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Knowledge Park-II, Greater Noida 201306, India
Correspondence Address:
R. SAHU, Department of Pharmacy, School of Medical & Allied Sciences, Galgotias University, Greater Noida 201310, India, E-mail: rakeshsahu1100@gmail.com
Pyridine is an imperative pharmacophore, a privileged scaffold and an exceptional heterocyclic system in the field of drug discovery which provides many opportunities in study/explore this moiety as an anticancer agent by acting on various receptors of utmost importance. Several pyridine derivatives are reported to inhibit tubulin polymerization, androgen receptors, human carbonic anhydrase, kinase, topoisomerase enzyme and many other targets for controlling and curing global health issue of cancer. Now a days in combination with other moieties researchers are focusing for development of pyridine new entities for the treatment of cancer. This review throws light on recent biological expansions of pyridine along with their structure activity relationships/molecular docking to deliver association between various synthesized newer derivatives and receptor sites.
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