Abstract
Proteomic Study of Nucleus Pulposus Cells in Degenerative Lumbar Intervertebral Disc
Department of Spine Surgery, Xiangdong Hospital Affiliated with Hunan Normal University, Zhuzhou, Hunan 412200, 1Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, 2Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of China
Correspondence Address:
Guohua Wang, Department of Spine Surgery, Xiangdong Hospital Affiliated with Hunan Normal University, Zhuzhou, Hunan 412200, People’s Republic of China, E-mail: w.guohua@outlook.com
To establish the information database of differentially expressed proteins in nucleus pulposus cells of the degeneration lumbar intervertebral disc. In this study, samples of nucleus pulposus cells from the degenerative lumbar intervertebral disc and normal lumbar intervertebral disc were collected. The tandem mass tag technique of proteomics was used to construct the map of differentially expressed proteome of nucleus pulposus cells between the lumbar intervertebral disc degeneration group and the control group. The differentially expressed proteins in nucleus pulposus cells in the degenerative lumbar intervertebral disc and the normal lumbar intervertebral disc are screened. Proteomics analysis of lumbar intervertebral disc degeneration provides some valuable differential protein markers for the diagnosis and treatment of intervertebral disc degeneration.
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