Abstract

To evaluate the protective effects of ulinastatin combined with dexmedetomidine on patients undergoing one lung ventilation. A total of 100 patients who underwent thoracoscopic partial lobectomy in our hospital were selected and randomly divided into control group (Group N), ulinastatin pretreatment group (Group U), dexmedetomidine continuous pumping group (Group D) and combined treatment group (Group U+D) (n=25). Their intraoperative data and objective indices reflecting the lung function at T1, T2 and T3 were compared. The expression levels of inflammatory factors were compared at T0, T1, T2, T3 and T4. Lung dynamic compliance and oxygenation index rose first and then declined, while respiratory index declined first and then rose in all patients from T1 to T3. At T3, lung dynamic compliance and oxygenation index were significantly higher, while respiratory index was significantly lower in Group U+D than those in the other groups (p<0.05). lung dynamic compliance, oxygenation index and respiratory index had significant differences in Group U and D compared with those in Group N, but they had no significant differences between Group U and D (p>0.05). The levels of inflammatory factors rose first and then declined in all patients from T0 to T4. At T3 and T4, the levels of pro-inflammatory factors were significantly lower, while the level of anti-inflammatory factor was significantly higher in Group U+D than those in the other groups (p<0.05). The levels of inflammatory factors had significant differences in Group U and D compared with those in Group N (p<0.05), but they had no statistically significant differences between Group U and D (p>0.05). Group U+D had a significantly lower incidence rate of postoperative pulmonary complications and a significantly shorter length of stay after surgery than those of Group U, D and N (p<0.05). Dexmedetomidine and ulinastatin can alleviate the damage caused by one lung ventilation to the lung to a certain extent and the combination of them has the optimum effect.